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Pinprick? (0-3) 0 (0-1.3) 0 (0-0) 0 0.089 Pain intensity (0-10) 0.7 (0-1.7) 0.2 (0-1.0) 23.5 0.422 Dynamic mechanical allodynia Q-tip 0 (0-0) 0 (0-0) 1.0 1.000 Foam brush 0 (0-0) 0 (0-0) 1.0 1.000 Vibration detection 128-Hz medica-grade tuning fork Perceived upon touch? (0-3) 3 (3-3) 3 (1.8-3) 0 0.054 Perceived after 5 s? (0-3) 2.0 (0.8-3) 1.0 (0-2.3) 9.5 0.254 Dynamic vibration detection (0-2) 1.0 (0-1.0) Rydel–Seiffer tuning fork Vibration detection threshold (x/8) 7.5 (7.0-8) 7.3 (6.8-8) 3.0 0.024 0.502 Dynamic vibration detection (0-2) 0.8 (0.3-1.0) Pinprick sensitivity Neurotip: sharp end Pain intensity (0-10) 2.2 (1.7-3.8) 2.5 (2.0-3.2) 47.5 0.777 Pressure pain sensitivity Threshold (mL) 4.8 (3.8-5.6) 3.8 (3.0-4.3) 24.5 0.026 0.563 Pain intensity (0-10) at 4 mL 2.0 (1.0-4.0) 1.8 (1.0-3.8) 57.0 0.887 Cold sensitivity Tolerance (s) 60 (60-60) 60 (60-60) 1.0 0.423 Pain intensity (0-10) at 30 s 0.8 (0.3-2.8) 0.8 (0-2.7) 48.0 0.801 Heat sensitivity Low heat level Tolerance (s) 60 (60-60) 60 (60-60) 5.0 0.423 Pain intensity (0-10) at 30 s 0.5 (0.3-2) 0 (0-1.1) 7.5 0.015 0.673 Medium heat level* Tolerance (s) 60 (60-60) 60 (60-60) 6.0 0.855 Pain intensity (0-10) at 30 s 2.5 (1.2-3.5) 2.3 (1.4-4.0) 49.0 0.456 Data are presented as median (interquartile range). The test statistic of Wilcoxon signed rank test (V) alongside the P values. The effect size is only reported for significant differences observed (r): 0.10 to The test statistic value comparing the static mechanical detection before and after eutectic mixture of local anesthetics application was not available (NA) because no change was observed for all participants.*Only 15 participants conducted the heat sensitivity tests at the medium heat level. Table 4 - Home quantitative sensory testing values before and after capsaicin cream application (n = 15). Before After Test statistic P Effect size Static mechanical detection (g) 1 (1-1) 1 (1-1) 1 1 Dynamic mechanical detection (0-2) Filament wheel 1.0 (1.0-1.8) Q-tip 2.0 (1.8-2.0) Static mechanical allodynia Filament wheel Pinprick? (0-3) 3 (2.0-3) 3 (0-3) 11.0 0.357 Pain intensity (0-10) 1.0 (0.7-2.2) 2.0 (1.0-3.3) 53.5 0.075 Neurotip: round end Pinprick? (0-3) 0 (0-1.0) 0 (0-0.5) 4.0 0.850

| 2 | 1 | 1 | 4 | 5 | 20 ||-------|-----------|---------|---------|-------|-------|-------|| 2 | 2 | 1 | 1 | 3 | 5 | 30 ||-------|-----------|---------|---------|-------|-------|-------|| 3 | 2 | 2 | 2 | 2 | 5 | 40 ||-------|-----------|---------|---------|-------|-------|-------|| 4 | 3 | 2 | 2 | 1 | 5 | 40 ||-------|-----------|---------|---------|-------|-------|-------|| 5 | 4 | 4 | 3 | 0 | 5 | 40 ||-------|-----------|---------|---------|-------|-------|-------|| 6 | 4 | 4 | 3 | 3 | 5 | 50 ||-------|-----------|---------|---------|-------|-------|-------|| 7 | 4 | 4 | 3 | 0 | 5 | 50 ||-------|-----------|---------|---------|-------|-------|-------|| 8 | 4 | 4 | 3 | 0 | 5 | 50 ||-------|-----------|---------|---------|-------|-------|-------|| 9 | 4 | 4 | 3 | 0 | 3 | 60 ||-------|-----------|---------|---------|-------|-------|-------|| 10 | 4 | 4 | 3 | 3 | 5 | 60 ||-------|-----------|---------|---------|-------|-------|-------|| 11 | 4 | 4 | 3 | 0 | 5 | 60 ||-------|-----------|---------|---------|-------|-------|-------|| 12 | 4 | 4 | 3 | 0 | 3 | 60 ||-------|-----------|---------|---------|-------|-------|-------|| 13 | 4 | 4 | 3 | 0 | 3 | 60 ||-------|-----------|---------|---------|-------|-------|-------|| 14 | 4 | 4 | 3 | 1 | 3 | 60 ||-------|-----------|---------|---------|-------|-------|-------|| 15 | 4 | 4 | 3 | 0 | 5 | 60 ||-------|-----------|---------|---------|-------|-------|-------|| 16 | 4 | 4 | 3 | 0 | 3 | 60 ||-------|-----------|---------|---------|-------|-------|-------|| 17 | 4 | 4 | 3 | 0 | 0 | 60 ||-------|-----------|---------|---------|-------|-------|-------|| 18 | 4 | 4 | 3 | 0 | 3 | 60

Pain intensity (0-10) 0.2 (0-1.3) 0.7 (0.2-1.3) 52.5 0.307 Dynamic mechanical allodynia Q-tip 0 (0-0) 0.7 (0-1.8) 55.0 0.006 0.788 Foam brush 0 (0-0) 1.0 (0.3-2.3) 78.0 0.003 0.841 Vibration detection 128-Hz medical-grade tuning fork Perceived upon touch? (0-3) 3 (2.0-3) 3 (1.5-3) 12.0 0.407 Perceived after 5 s? (0-3) 0 (0-1.0) 0 (0-1.5) 13.0 0.930 Dynamic vibration detection (0-2) 1.0 (0.3-1.2) Rydel–Seiffer tuning fork Vibration detection threshold (x/8) 7.3 (6.8-7.5) 6.8 (6.2-7.4) 23.0 0.224 Dynamic vibration detection (0-2) 1.0 (1.0-1.0) Pinprick sensitivity Neurotip: sharp end Pain intensity (0-10) 2.3 (1.7-3.5) 2.7 (1.7-3.8) 54.0 0.950 Pressure pain sensitivity Threshold (mL) 3.8 (3.3-5.7) 4.5 (4.2-5.3) 76.5 0.363 Pain intensity (0-10) at 4 mL 2.0 (1.3-3.8) 3.7 (2.5-5.0) 88.5 0.003 0.795 Cold sensitivity Tolerance (s) 60 (60-60) 60 (60-60) 0 0.371 Pain intensity (0-10) at 30 s 1.0 (0-2.0) 0 (0-0.6) 7.5 0.086 Heat sensitivity Low heat level Tolerance (s) 60 (60-60) 4.6 (3.3-60) 0 0.006 0.788 Pain intensity (0-10) at 30 s 0 (0-0.3) 10 (5.2-10) 120.0 0.884 Medium heat level* Tolerance (s) 60 (60-60) 60 (25.5-60) 0 0.371 Pain intensity (0-10) at 30 s 1.7 (0.3-3.8) 5.3 (3.8-9.1) 21.0 0.036 0.901 Data are presented as median (interquartile range). The test statistic of Wilcoxon signed rank test (V) alongside the P values. The effect size is only reported for significant differences observed (r): 0.10 to *Only 6 participants conducted the heat sensitivity tests after capsaicin cream was applied. 4. Discussion Overall, significant weak-to-moderate associations were observed between specific home and LQST results. Moreover, the HQST tool-kit presented is able to assess changes in sensory and pain processing after lidocaine or capsaicin cream is applied. No adverse events relating to HQST tool-kit were reported, and participants reported high acceptability of the HQST tool-kit. Quantitative sensory testing poses as an advantage in the examination of all modalities of the somatosensory function and has gained a lot of attention for a mechanism-based approach to pain treatment. The Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials conducted a meeting concluding that the current findings on sensory testing support its applicability as a diagnostic,